Development of a Pharmaceutical Protein Production Technology Using Transgenic Rice
In this proposal, we aim to develop production technologies for antibody therapeutics and vaccine proteins using transgenic rice. Specifically, we will generate transgenic rice lines that express antibody drugs and a malaria vaccine protein in the rice endosperm, and evaluate whether these proteins are suitable for pharmaceutical use in terms of functionality and quality. In […]
Next‑Generation Pest Control Strategies Using Multi‑Target RNAi and Nanocapsule Technologies
As a novel mite control strategy to replace conventional chemical pesticides, we will develop a multi‑target RNA interference (RNAi) technology that simultaneously targets multiple genes, together with a nanocapsule delivery system that enables efficient introduction of double‑stranded RNA (dsRNA) into the cells of hard‑to‑control pest arthropods.
Development of Next-Generation Rice Capable of Mass-Producing Antimicrobial Proteins Derived from Fish Mucus and Verification of Its Commercial Potential
We have identified a protein derived from fish mucus that exhibits strong antimicrobial activity against various pathogenic bacteria and have successfully achieved its synthesis in rice. However, because the current version of the protein contains artificial sequences at its termini, there are concerns regarding potential regulatory restrictions. In this study, we aim to establish the […]
Establishing Insect Oil as a New Lipid Resource: A Challenge Toward Sustainable Resource Circulation
By leveraging the exceptional antioxidant properties of insect oil that we have identified, this project aims to establish insect oil as a new industrial lipid resource. In addition, these properties will be applied to feed derived from insect proteins to enhance their added value, thereby creating a market foundation for insect-based feed. Through these efforts, […]
Modeling the Production of Thickening Polysaccharides via Carob Cell Culture Using Genomic Information
Galactomannan, a thickening polysaccharide derived from the endosperm of carob (locust bean), is widely used as a food texture modifier; however, ensuring its sustainable supply remains difficult. To address this challenge, we will leverage genomic information and plant cell culture technologies to establish high-producing galactomannan cell lines through genome editing and/or genetic engineering, and build […]
Research and Development of Artificial Antimicrobial Enzymes for Animals to Reduce the Risk of Antimicrobial Resistance
Antimicrobial enzymes are bactericidal agents that kill bacteria by disrupting the bacterial cell wall, and are expected to be socially implemented as alternatives to conventional antibiotics. In this research project, aiming to create innovation in the veterinary antimicrobial market, we will develop technologies for generating high‑performance artificial antimicrobial enzymes using data science and synthetic biology […]
Research on the Use of Disulfide‑Rich Peptides to Reduce Production Costs in Cultured Meat
Ant venom contains disulfide‑rich peptides that act on animal growth factor receptors for extended periods. In this project, we aim to leverage stable, highly active disulfide‑rich peptides with growth factor–like activity as cell proliferation supplements for cultured meat production. By applying these peptides during cell expansion, we seek to significantly reduce production costs in cultured […]
Development of Organelle Genome Editing Technology for Identifying Crop Variety Breeders
High‑value Japanese crop varieties, such as Shine Muscat grapes, have been illicitly propagated overseas, leading to infringement of breeders’ rights. In this proposal, to protect breeders’ rights and to support the competitiveness and sustainable growth of Japan’s agriculture, forestry, fisheries, and food industries, we aim to develop a practical breeder identification technology based on genetic […]
